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Simple Modular Architecture Research Tool (SMART) is a biological database that is used in the identification and analysis of protein domains within protein sequences.cite-ref-pmid9600884-1-0[1]cite-ref-pmid18978020-2-0[2] SMART uses profile-hidden Markov models built from multiple sequence alignments to detect protein domains in protein sequences. The most recent release of SMART contains 1,204 domain models.cite-ref-3[3] Data from SMART was used in creating the Conserved Domain Database collection and is also distributed as part of the InterPro database.cite-ref-pmid12230031-4-0[4] The database is hosted by the European Molecular Biology Laboratory in Heidelberg.

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cite-note-pmid9600884-11. ↑ citerefschultzmilpetzborkponting1998Schultz J, Milpetz F, Bork P, Ponting CP (May 1998). "SMART, a simple modular architecture research tool: identification of signaling domains" (PDF). Proc. Natl. Acad. Sci. U.S.A. 95 (11): 5857–64. Bibcode:1998PNAS...95.5857S. doi:10.1073/pnas.95.11.5857. PMC 34487. PMID 9600884.

cite-note-pmid18978020-22. ↑ citerefletunicdoerksbork2009Letunic I, Doerks T, Bork P (January 2009). "SMART 6: recent updates and new developments". Nucleic Acids Res. 37 (Database issue): D229–32. doi:10.1093/nar/gkn808. PMC 2686533. PMID 18978020.

cite-note-33. ↑ citerefletunicdoerksbork2015Letunic, Ivica; Doerks, Tobias; Bork, Peer (January 2015). "SMART: recent updates, new developments and status in 2015". Nucleic Acids Research. 43 (Database issue): D257–260. doi:10.1093/nar/gku949. ISSN 1362-4962. PMC 4384020. PMID 25300481.

cite-note-pmid12230031-44. ↑ citerefmulderapweilerattwood2002Mulder NJ, Apweiler R, Attwood TK, et al. (September 2002). "InterPro: an integrated documentation resource for protein families, domains and functional sites". Brief. Bioinformatics. 3 (3): 225–35. doi:10.1093/bib/3.3.225. PMID 12230031.

• SMART web site